Background: Thermal cardiac ablation may cause phrenic nerve (PhN) palsy. Pulsed electric fields (PEF) induce cell death independently from thermal processes, potentially enabling cardiac ablation underlying the PhN without disrupting its function or morphology.
Objective: This preclinical study evaluates cardiac-based PEF treatments on the morphology and function of the PhN.... MORE
Background: During pulsed field ablation (PFA), electric pulses induce reversible (R) or irreversible (IR) injury on cardiac myocytes.
Objective: To perform histological examination of acute ventricular lesions produced by PFA, determining R and IR injury boundaries in a swine heart model.... MORE
Background: Pulsed electric field (PEF) therapy kills cells in targeted tissues via mechanisms dependent on local field effects, where different tissue layers will distort this distribution.
Objective: Numerically evaluate the implications of the heterogeneous electrical conductivity tissues surrounding cardiac ablation sites on the spatial distribution of PEF ablation effects.... MORE
Background: Thermal cardiac ablation can cause collateral esophageal injury that may degenerate to an atrio-esophageal fistula. Pulsed electric fields (PEFs) induce cell death independently from thermal processes, potentially preventing esophageal damage. However, the implications of worst-case treatment effects to the esophagus must be characterized.
Objective: This preclinical animal study evaluates the acute and chronic effects of PEFs to esophageal tissue.... MORE