Abstract Publications

January 12, 2022

Biphasic Focal Monopolar Pulsed Electric Field Therapy: Preserved Phrenic Nerve Function and Anatomy (R. Neal, Q. Castellvi, J. Evans)

Background: Thermal cardiac ablation may cause phrenic nerve (PhN) palsy. Pulsed electric fields (PEF) induce cell death independently from thermal processes, potentially enabling cardiac ablation underlying the PhN without disrupting its function or morphology.

Objective: This preclinical study evaluates cardiac-based PEF treatments on the morphology and function of the PhN.

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January 12, 2022

Effects of Contact Force on Lesion Size During Pulsed Field Ablation (Hiroshi Nakagawa, MD, PhD, Quim Castellvi, PhD, Robert Neal, PhD)

Background: Effects of contact force (CF) on lesion formation during pulsed field ablation (PFA) have not been validated.

Objective: To determine the relationship between average CF and lesion size during PFA using a swine beating heart model.

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January 12, 2022

Histological Characterization of Reversible and Irreversible Ventricular Lesion Boundaries Produced by Pulsed Field Ablation

Background: During pulsed field ablation (PFA), electric pulses induce reversible (R) or irreversible (IR) injury on cardiac myocytes.

Objective: To perform histological examination of acute ventricular lesions produced by PFA, determining R and IR injury boundaries in a swine heart model.

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January 12, 2022

The Influence of Heterogeneous Environments on Pulsed Electric Field Therapy Effects: Implications in Cardiac Ablation (Q. Castellvi, R. Neal)

Background: Pulsed electric field (PEF) therapy kills cells in targeted tissues via mechanisms dependent on local field effects, where different tissue layers will distort this distribution.

Objective: Numerically evaluate the implications of the heterogeneous electrical conductivity tissues surrounding cardiac ablation sites on the spatial distribution of PEF ablation effects.

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January 9, 2022

The Susceptibility and Recovery of Esophageal Tissue Layers to Pulsed Electric Fields (R. Neal, Q. Castellvi, J. Evans)

Background: Thermal cardiac ablation can cause collateral esophageal injury that may degenerate to an atrio-esophageal fistula. Pulsed electric fields (PEFs) induce cell death independently from thermal processes, potentially preventing esophageal damage. However, the implications of worst-case treatment effects to the esophagus must be characterized.

Objective: This preclinical animal study evaluates the acute and chronic effects of PEFs to esophageal tissue.

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